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Review Article
- Effectiveness and Safety of Low-Level Laser Treatment for Lumbar Disc Herniation: A Systematic Review and Meta-Analysis
- Sang Jun Lee, Seung Jin Noh, Jeong Rock Kim, Kyung Bok Park, Sae-rom Jeon, Yejin Hong, Dongwoo Nam
- Perspect Integr Med. 2023;2(3):155-163. Published online October 23, 2023
- DOI: https://doi.org/10.56986/pim.2023.10.003
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- 2 Citations
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Graphical Abstract
Abstract
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Supplementary Material 
- Background
Low-level laser treatment (LLLT) is used to treat low back pain (LBP) however, its effects on lumbar disc herniation (LDH) remain unclear. The safety and effectiveness of LLLT for LDH was determined using a systematic review of randomized clinical trials.
Methods
Studies on LLLT in adults with LDH were identified from 12 worldwide databases. A risk of bias assessment and a meta-analysis with categorization according to the type of control used (inactive, active, or add-on) was performed. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation.
Results
The quantitative analyses included five studies. LLLT was significantly more effective at treating LDH [leg pain visual analog scale (VAS) mean difference (MD): -1.90, 95% confidence interval (CI): -2.01, -1.80, I2 80%; LBP VAS MD: -0.79, 95% CI: -0.87, -0.71, I2 80%] than inactive controls (placebo or sham). The quality of the evidence ranged from “low” to “very low.” As an add-on to usual care, LLLT significantly improved pain intensity and disability compared with usual care (leg pain VAS MD: -2.52, 95% CI: -2.65, -2.40, I2 97%; LBP VAS MD: -1.47, 95% CI: -1.58, -1.36; Oswestry Disability Index MD: -4.10, 95% CI: -4.55, -3.65, I2 6%). However, the quality of the evidence ranged from “moderate” to “low.”
Conclusion
LLLT significantly improved outcomes compared with the inactive controls, but was not more effective than usual care for LDH. In combination with usual care, LLLT was significantly more effective than usual care alone highlighting the potential of LLLT. -
Citations
Citations to this article as recorded by
- Effectiveness of high-intensity laser therapy in patients with spinal radiculopathy: a systematic review with meta-analysis
Hernán Andrés de la Barra Ortiz, Nivaldo Antonio Parizotto, Richard Eloin Liebano
Lasers in Medical Science.2025;[Epub] CrossRef - Low-Level Laser Therapy in Osteoarthritic Pain: A Narrative Review with an approach to integrated clinical use.
S.N. Hennessy, G.D. Corcoran
Osteoarthritis and Cartilage Open.2025; : 100685. CrossRef
- Effectiveness of high-intensity laser therapy in patients with spinal radiculopathy: a systematic review with meta-analysis
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