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Original Article
- Effectiveness and Safety of Integrative Korean Medicine Treatment for Cervical Disc Herniation with Radiculopathy: One-year Follow-up Results of a Prospective Observational Study
- Su Won Lee, Yong-jun Ahn, Suna Kim, Yeonsun Lee, Hyun-Woo Cho, Yoon Jae Lee, In-Hyuk Ha
- Perspect Integr Med. 2026;5(1):17-27. Published online February 11, 2026
- DOI: https://doi.org/10.56986/pim.2026.02.004
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Graphical Abstract
Abstract
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Supplementary Material 
- Background
Cervical disc herniation (CDH) often accompanies radiculopathy causing pain in the neck and upper extremities that interferes with daily life. The prevalence of CDH is increasing. The treatment methods recommended are primarily conservative.
Methods
In this prospective, single-arm, multicenter, observational study there were 120 patients diagnosed in the past 12 months with CDH (disc protrusion or more severe conditions) accompanied by radiculopathy. Patients received integrative Korean medicine treatment (acupuncture, electroacupuncture, pharmacopuncture, herbal medicine, cupping therapy, and Chuna therapy), approximately twice a week for 2 months, and outcomes were measured. The numeric rating scale, and visual analog scale were used for assessing neck and arm pain, and the neck disability index, patient global impression of change, EuroQol-5-dimension, work productivity and activity impairment questionnaire, and range of motion assessed how pain affected daily activities.
Results
Out of 120 patients, 115 completed 2-months treatment, and 114 responded at the 1-year follow-up. The numeric rating scale score for neck or arm pain showed a reduction of 3.96 points (95% CI, 3.63, 4.29) from baseline to 8 weeks, which further improved (95% CI, 4.09, 4.75) at 1 year. Similarly, the visual analog scale score for neck and arm pain, quality of life measures, and function-related measures also showed improvement from baseline, maintaining these gains at 1 year.
Conclusion
This observational study suggested that using Korean medicine treatment, a conservative treatment method, as the intervention, may provide long-term benefits in reducing pain and improving function and quality of life for patients with CDH accompanied by radiculopathy.
Protocol
- Study Protocol for a Randomized Pragmatic Clinical Trial Evaluating Pharmacopuncture Versus Acupuncture for Chronic Neck Pain
- Ju Yeon Kim, Suna Kim, Yeonsun Lee, Hyun-Woo Cho, Yejin Hong, Dongwoo Nam, Yeoncheol Park, Eun-Jung Kim, Sook-Hyun Lee, Yoon Jae Lee, In-Hyuk Ha
- Perspect Integr Med. 2025;4(3):181-189. Published online October 22, 2025
- DOI: https://doi.org/10.56986/pim.2025.10.007
- 803 View
- 26 Download
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Graphical Abstract
Abstract
PDFSupplementary Material
- Background
Neck pain is a common musculoskeletal disorder, which is becoming increasingly common with the rise in computer and smartphone use. For many, this condition leads to chronic discomfort, and disability in daily life. Although pharmacopuncture represents a major treatment modality for neck pain in Korean medicine, its effectiveness and safety as compared with standard acupuncture has not been thoroughly investigated.
Methods
A study protocol for a multicenter, pragmatic, randomized clinical trial was designed with a parallel-group approach. A total of 128 participants, each experiencing chronic neck pain for at least 3 months, will be recruited. Participants will be randomly assigned to either the pharmacopuncture or acupuncture group and receive treatment twice weekly for 4 weeks. The primary outcome will be the change in score for neck pain, as assessed using the numeric rating scale, 5 weeks after baseline. Secondary outcomes will include evaluations using the visual analog scale, Northwick Park Questionnaire, Neck Disability Index, Patient Global Impression of Change, Health-Related Quality of Life Instrument with eight items, and the EuroQol-5 Dimension. In addition, a cost-effectiveness analysis will be conducted and reported separately.
Discussion
The rigorous study design is intended to ultimately provide practical evidence for clinicians and policymakers regarding the use of pharmacopuncture treatment for chronic neck pain. By directly comparing its effectiveness with standard acupuncture, the results of the trial outcomes will offer insights that may inform future healthcare decisions. Trial registration: This protocol has been registered at ClinicalTrials.gov (NCT06520462) on July 25, 2024.
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