Perspectives on Integrative Medicine

Protocols

A Cross-Sectional Comparative Study of Quantitative Electroencephalogram Characteristics According to the Presence or Absence of Central Neuropathic Pain After Stroke: Study Protocol: Youngjo So, Jiwoo Kim, Hyeon-Gyu Cho, Sangho Ji, Sunny Kang, Sangkwan Lee, Cheol-Hyun Kim; Perspect Integr Med. 2026;5(2):152-160. Published online June 19, 2026; DOI: https://doi.org/10.56986/pim.2026.06.009

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Graphical Abstract Abstract PDF: Background
Central post-stroke pain (CPSP) is a representative central neuropathic pain syndrome caused by lesions of the thalamus or spinothalamic tract. Current diagnostic approaches rely on subjective symptom reporting. Quantitative electroencephalography (qEEG) has gained attention as a noninvasive neurophysiological biomarker with the potential to overcome these limitations.
Methods
A total of 50 stroke patients will be recruited at a single center and allocated into either a CPSP group (n = 25) or a control group without central neuropathic pain (n = 25). Using a 2-channel frontal EEG device (Fp1-Fp2), resting-state EEG will be recorded for 5 minutes under both eyes-open and eyes-closed conditions, followed by a 2-minute EEG acquisition during cold stimulation. After artifact removal, frontal asymmetry indices, the delta-to-alpha ratio, and the delta-theta to beta-alpha ratio will be computed. These qEEG parameters will be compared between groups alongside clinical variables including the Neuropathic Pain Symptom Inventory, Patient Health Questionnaire-9, and relevant medical history.
Conclusion
This study seeks to identify distinctive qEEG features such as increased slow-wave activity and altered frontal asymmetry in patients with CPSP, thereby providing foundational evidence for establishing qEEG as an objective tool for early diagnosis and standardized assessment of CPSP. Although the single-center design and the limited spatial resolution of the 2-channel EEG system represent inherent constraints, this study protocol is expected to serve as an essential basis for future multi-channel qEEG investigations, machine learningbased analyses, and individualized intervention assessments in CPSP research.

A Protocol for the Validation of Novel Sham Acupuncture in Patients Who Have Had a Stroke: Sung Min Lim; Perspect Integr Med. 2024;3(3):168-171. Published online October 23, 2024; DOI: https://doi.org/10.56986/pim.2024.10.006

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Graphical Abstract Abstract PDF Supplementary Material: Background
A sham control group enhances the quality of clinical trials by controlling for the placebo effect. To ensure rigorous blinding to enhance the quality of clinical trials on acupuncture treatment it is important to develop a more sophisticated sham needle. Discrepancies in perceived needling sensation and treatment expectations between patients and healthy volunteers may affect study outcomes. Thus, it may be inappropriate to generalize the findings of a sham needle validation study in healthy adults to patients who have had a stroke. Therefore, this is a protocol for a clinical trial in patients who have had a stroke to validate a newly developed sham needle to be used in double-blind trials.
Methods
Sixty-six patients who have had a stroke will be randomly assigned to the verum or sham needle group using a 1:1 ratio. As the verum and sham needles are identical in appearance, both participants and practitioners will be unaware of the needle type used for acupuncture treatment. After the acupuncture procedure, the participants will be asked whether they believe they received the verum or sham acupuncture treatment and indicate penetration, pain, and de qi sensation for each acupuncture point. A between-group comparison of needle-related adverse events will be performed.
Discussion
This double-blind randomized controlled trial will be the first study to validate a newly developed sham acupuncture needle for patients who have had a stroke. The results of this study may inform clinical trial study design for acupuncture treatment of patients who have had a stroke.

Editorial

A Pilot Trial of Integrative Medicine for Stroke Rehabilitation: Expert Recommendations for the Development and Sustainability of Integrative Medicine: Chihyoung Son, Go-Eun Lee, Joo-Hee Seo, Inae Youn, Jin-Won Kim; Perspect Integr Med. 2024;3(1):1-6. Published online February 22, 2024; DOI: https://doi.org/10.56986/pim.2024.02.001

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Graphical Abstract Abstract PDF

Background
Strategies towards development and sustainability of integrative treatment in stroke rehabilitation medicine are needed. National expert recommendations based on the implementation of Integrative Medicine (IM) in stroke rehabilitation and IM outcomes would be invaluable.
Methods
A pilot study was performed and the effectiveness of combining Korean traditional medicine and Western conventional medicine in post-stroke patients (ischemic stroke n = 15 and hemorrhagic stroke n = 4) was evaluated, and recommendations were developed through consensus with physicians in national centers of rehabilitative medicine. Outcome measures [Korean Modified Barthel Index (K-MBI), Korean Mini Mental State Examination (K-MMSE), Modified Rankin Scale (mRS), and EuroQol 5-dimension 5-level (EQ-5D-5L) assessment were used at baseline, 4, 8 (K-MBI, K-MMSE, mRS, and EQ-5D-5L) and 12 weeks post treatment (EQ-5D-5L and mRS).
Results
Improvements were observed in functional and cognitive abilities at 8 weeks (K-MBI score p = 0.0062; K-MMSE score p = 0.046). Quality of life improvements (EQ-5D-5L) were observed but were not statistically significant. The disability assessment (mRS) indicated a gradual improvement from baseline to 12 weeks. No adverse events were reported. For effective, patient-centered IM treatment: (1) build a strong evidence base for IM as compared with Western medicine alone or traditional medicine alone; (2) active expert collaboration; (3) IM promotion in public medical institutions; and (4) continued government support.
Conclusion
Functional and cognitive abilities of stroke patients statistically significantly improved following 8 weeks of IM treatment. Strategies have been suggested towards the development and sustainability of IM treatment in stroke rehabilitation medicine.

Citations

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Patient Satisfaction with Advanced Medical Technology-Based Treatments in Integrative Medicine: A Structural Equation Modeling Approach Among Patients with Chronic Diseases
Prajisteanu Constantin-Bogdan, Anamaria-Cătălina Radu, Georgeta Ionescu, Daniel Diaconescu, George Mihail Man
Healthcare.2026; 14(11): 1485. CrossRef

Original Article

An Observational Study on the Anatomical Characteristics of Acupoint CV23 (Lianquan) with Ultrasonography: Hongmin Chu, Seongjun Park, Jaehyo Kim, Wonbae Ha, Seung Bum Yang, Kyungho Kang, Jongho Kim, Jungtae Leem, Sanghun Lee; Perspect Integr Med. 2023;2(1):49-55. Published online February 21, 2023; DOI: https://doi.org/10.56986/pim.2023.02.007

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Graphical Abstract Abstract PDF

Background
Acupoint CV23 is one of the most commonly used acupoints for the treatment of post-stroke dysphagia and tongue pain. However, care must be taken during the procedure to consider the position of glands and blood vessels in the subcutaneous space of the acupoint. Needling depths to the geniohyoid muscle reportedly range from 0.4 to 3.3 cm. Using ultrasound imaging, we aimed to observe the anatomical characteristics around acupoint CV23 to derive a safe needling depth.
Methods
Ultrasound images of acupoint CV23 accessed from the Standard Ultrasound Image of Acupoint database were retrospectively analyzed for 30 participants aged in their 20s and 30s (15 male, 15 female), and the depth from the skin to the geniohyoid muscle was measured. Correlations between the needling depth and anthropometric factors (such as neck circumference) were analyzed.
Results
The average needling depth to the geniohyoid muscle was 1.59 ± 0.49 cm (male; 1.43 ± 0.52 cm, female, 1.75 ± 0.42 cm, p = 0.03). The geniohyoid muscle, anterior digastric muscles, and genioglossus muscle were observed in the subcutaneous area of acupoint CV23, and a risk of sublingual gland damage needs to be considered for oblique insertion of the acupuncture needle. No statistically significant correlations between the needling depth and anthropometric factors were observed.
Conclusion
Acupoint CV23 has a relatively shallow needling depth, and considering the presence of blood vessels and glands in the sublingual space, visualizing the surrounding anatomical structures using ultrasound was helpful to ensure safe needling practice.

Citations

Citations to this article as recorded by

Efficacy of ultrasound-guided pharmacopuncture: A systematic review and meta-analysis
Jinho Lee, Sook-Hyun Lee, Yoon Jae Lee, Ju Yeon Kim, In Heo, Jae-Heung Cho, Byung-Kwan Seo, Dong Kun Ko, In-Hyuk Ha
Medicine.2025; 104(11): e41733. CrossRef
Survey on the current usage of ultrasound-guided procedures in Korean Medicine Clinics and Hospitals
Ju Yeon Kim, Jung Min Yun, Sook-Hyun Lee, Yoon Jae Lee, Dong Kun Ko, In Heo, Woo-Chul Shin, Jae-Heung Cho, Byung-Kwan Seo, In-Hyuk Ha
Medicine.2024; 103(14): e37659. CrossRef

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